Our goal is to identify molecular interactions between mammal hosts and African trypanosomes that affect the development of protective immune responses as well as pathophysiologic processes. African trypanosomes are flagellated protozoa that cause sleeping sickness in people and Nagana in domestic animals. These diseases are fatal if left untreated. The diseases are endemic in the humid and semi-humid zones of Africa affecting a landmass of 10 million km 2 and 36 countries.
Department of Veterinary and Animal Sciences
A male factor is responsible for about half of the cases of equine infertility: this fact highlights the need for a better understanding of the molecular basis of male equine infertility both at the genetic as well as at the biochemical level.This project is relevant for the study of male infertility from several perspectives: 1) results of the experiments will provide a significant advance in understanding at the molecular level the mechanisms of the causes of male infertility.
There is concern over the presence of pollutants in our water supply. Among the pollutants that have elicited the greatest alarm are those that can alter the development and reproduction of aquatic organisms and potentially harm human health. These chemicals, generally referred to as endocrine disrupting compounds (EDCs), enter waterways as runoff from farms, effluent from wastewater treatment and manufacturing plants, and leachate from septic systems.
The sustainability of water resources and of green spaces will become increasingly important for quality of life in the future. The efficient utilization of turfgrasses to remediate organic pollutants in these efforts can be an important component of a sustainability strategy. Research has established that significant differences exist between plants in their remediation abilities: different abilities of plants to adsorb and absorb pollutants; different exudates being released from the root systems; and different microbial populations associated with roots of different plants.
Mitochondria are critical for production of ATP, the energy currency of a cell, but glucose utilization varies greatly among cell types. Inherited mitochondrial disorders affect neural tissues most prominently revealing the vulnerability of these tissues. In mice, prolonged exposure to mitochondrial toxins can lead to symptoms that mimic Parkinson's disease. The mammary gland is a tissue that, in its resting state, has relatively modest energy requirements.