The relationship between domesticated animals and humans is a close one, and has existed for at least ten thousand years. It is important to understand the immune defenses of many animals, in addition to the immune defenses of humans and mice. Animals have evolved many different ways of responding to bacteria and viruses. Many diseases threatening humans are zoonotic, which means that they are shared between humans and animals.
Department of Veterinary and Animal Sciences
This grant is a "proof-of-principle" proposal to determine if imidacloprid, a neonicotinoid insecticide, causes obesity and insulin resistance (IR) in the insect obesity and IR model, D. melanogaster, in a manner similar, if not identical, to the effects seen with this compound when administered to mice.
The etiology of breast cancer is complex and varied. Many of the major risk factors for breast cancer, including age, reproductive history, and family history of cancer, are not modifiable. There is a great need to provide women with evidence based advice on how they can reduce their risk of developing breast cancer. Research has shown that compounds in fruits and vegetables have anti-cancer properties and most people agree that a diet rich in nutritious fruits and vegetables may help prevent breast cancer. However, the ways in which such a diet reduces risk remain unknown.
The aim of this project is to enhance our understanding of the ovarian, embryonic and uterine factors that regulate developmental competence of oocytes, pre-implantation embryo development and uterine conditions so that the declining fertility rates and increased embryonic losses among dairy cattle as well as beef cattle and sheep, can be overturned. Therefore, by reversing these declining rates of fertility, we expect to make agricultural production more efficient, profitable, and competitive.
Our goal is to identify molecular interactions between mammal hosts and African trypanosomes that affect the development of protective immune responses as well as pathophysiologic processes. African trypanosomes are flagellated protozoa that cause sleeping sickness in people and Nagana in domestic animals. These diseases are fatal if left untreated. The diseases are endemic in the humid and semi-humid zones of Africa affecting a landmass of 10 million km 2 and 36 countries.