Mitochondria are critical for production of ATP, the energy currency of a cell, but glucose utilization varies greatly among cell types. Inherited mitochondrial disorders affect neural tissues most prominently revealing the vulnerability of these tissues. In mice, prolonged exposure to mitochondrial toxins can lead to symptoms that mimic Parkinson's disease. The mammary gland is a tissue that, in its resting state, has relatively modest energy requirements.
Department of Veterinary and Animal Sciences
Mitochondria are cellular organelles which are often referred to as the "powerhouse" of the cell. Their many functions include generating the chemical energy utilized by cells, as well as roles in cell signaling, differentiation, cell growth and even cell death. It has been shown that chronic exposures to organic pesticides such as Rotenone, which inhibits mitochondrial function, can result in pathological conditions such as Parkinson's disease.
Laminitis is a crippling disease that affects about one-percent of the more than nine million horses in North America. The cost of laminitis to the horse industry exceeds $1 billion annually, predominantly from loss of use of the affected animals rather than medical costs. Laminitis results from failure of the digital laminae, which suspend a horse's distal phalanx, and thus the axial skeleton and all that is attached to it, within the hoof capsule. The laminae are composed of a hoof wall-associated epidermal layer and a distal phalanx-associated dermal layer.
The genes within the genome (genetic code) of cattle need to be identified and defined before variability of these genes among cattle (individuals and breeds) can be identified. One goal is to determine whether such variations when found are associated with enhanced or decreased resistance to infectious diseases. The cattle genome has been largely sequenced (that is, the genetic code 'read'), and now one of the purposes of the international community effort is to annotate the bovine genome (define genes within the genetic code).