My laboratory is developing high throughput metabolic profiling assays in order to screen for mutants in complex regulatory pathways. Our model system is the small flowering plant, Arabidopsis thaliana, and we are characterizing the regulation of the signaling molecule, auxin. Auxin is fundamentally important in plant growth and development as a regulator of numerous biological processes. The primary plant auxin, indole-3-acetic acid (IAA) is tightly regulated through a network of redundant pathways, including biosynthesis, inactivation, transport and signal transduction. In piecing together these pathways, a variety of visual screens have identified candidate genes, but there are many more genes that have yet to be identified.