Mounting epidemiological and experimental evidence consistently indicates that obesity is a robust risk factor, with 50~100% increase in risk for CRC. As obesity has reached an epidemic level and increases in the scope of the problem are projected, it is critical to understand the mechanism(s) responsible for the link and thereby to develop preventive strategies. The ultimate goal is, through the completion of this project, to facilitate the development of preventive approaches to diminish dietary obesity associated CRC.
It is especially important to pursue research on bioactive food components at this time because it has the potential of identifying a novel avenue for targeting dietary prevention strategies to help alleviate the growing medical costs and societal burden related to diet-based problems in the area of obesity and chronic disease. The current project will investigate the effects of a bioactive food component called sulforaphane, which is found in broccoli and other cruciferous vegetables, on basic cellular functions using cell culture and animal (mice) models.