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Department of Veterinary and Animal Sciences

Metalloproteinases and Pathological Tissue Remodeling in Equine Laminitis

Laminitis is a crippling disease that affects about one-percent of the more than nine million horses in North America. The cost of laminitis to the horse industry exceeds $1 billion annually, predominantly from loss of use of the affected animals rather than medical costs. Laminitis results from failure of the digital laminae, which suspend a horse's distal phalanx, and thus the axial skeleton and all that is attached to it, within the hoof capsule. The laminae are composed of a hoof wall-associated epidermal layer and a distal phalanx-associated dermal layer.

National Animal Genome Research Program

The genes within the genome (genetic code) of cattle need to be identified and defined before variability of these genes among cattle (individuals and breeds) can be identified. One goal is to determine whether such variations when found are associated with enhanced or decreased resistance to infectious diseases. The cattle genome has been largely sequenced (that is, the genetic code 'read'), and now one of the purposes of the international community effort is to annotate the bovine genome (define genes within the genetic code).

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