Dr. Stephen Rich, Professor of Microbiology and Director of the UMass Laboratory of Medical Zoology, and Dr. Saravanan Thangamani, Professor of Microbiology and Immunology at Upstate Medical University in Syracuse, NY discuss what is currently known about tick-borne viruses, including Powassan virus. Dr. Thangamani studies the serosurveillance of vector-borne (tick and mosquito) diseases including the effect of co-infection on the clinical outcome of Lyme disease and Powassan encephalitis.