Dietary factors are important predictors of long term health and the incidence of chronic disease. Laboratory methods will be employed, primarily in vitro models, such as in vitro digestion and tissue cultures, which will be used to evaluate the bioactivity of nutrients and other food bioactives to understand the mechanisms. The investigator will seek to advance the science of defining the role of bioactive dietary constituents for optimal human health. This will provide fertile grounds for ongoing collaborations and future collaborative research and grant proposal development.